Table 4. Database Scan results using various homology detection methods for Target Dataset.
OCRS | PSI-BLAST | HMMER | HHpred | FASTA search | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Fold Class and Title | #Fold | #Hits | EFF | #Hits | EFF | #Hits | EFF | #Hits | EFF | #Hits | EFF |
All beta Proteins | |||||||||||
GFP-like protein | 273 | 273 | 100 | 216 | 79 | 228 | 84 | 263 | 96 | 248 | 91 |
Cupredoxin-like proteins | 120 | 117* | 98 | 110 | 92 | 108 | 90 | 106 | 88 | 103 | 86 |
Acid Proteases | 578 | 485 | 84 | 480 | 83 | 462 | 80 | 472 | 82 | 514 | 89 |
Ribosomal Protein L14 | 291 | 260 | 87 | 123 | 42 | 210 | 72 | 234 | 80 | 221 | 76 |
Alpha and beta (α + β) Proteins | |||||||||||
β-Grasp (Ubiquitin-like) protein | 400 | 363 | 90 | 265 | 66 | 156 | 39 | 327 | 82 | 304 | 76 |
Nucleoside Triphosphate Hydrolase | 530 | 492 | 93 | 370 | 70 | 369 | 70 | 508 | 96 | 514 | 97 |
RNAase A-like proteins | 319 | 312 | 98 | 251 | 79 | 289 | 91 | 310 | 97 | 299 | 94 |
Cysteine Proteinases | 198 | 170 | 86 | 132 | 66 | 144 | 73 | 164 | 83 | 172 | 87 |
Alpha and beta (α/β) Proteins | |||||||||||
50 S Ribosomal Protein L25 | 111 | 111* | 100 | 74 | 66 | 74 | 67 | 107 | 96 | 100 | 90 |
50 S Ribosomal Protein L6P | 317 | 282 | 89 | 155 | 49 | 212 | 67 | 264 | 82 | 285 | 90 |
Difydrofolate reductase-like proteins | 272 | 248 | 91 | 216 | 79 | 238 | 88 | 237 | 87 | 242 | 89 |
Pyruvate kinase N-terminal domain | 65 | 61 | 94 | 46 | 71 | 48 | 74 | 63 | 97 | 60 | 93 |
Here, table lists the total number of identified protein homolog during the fold scan against the PDB and the fold detection efficiencies of each method. Here #hits indicates structural fold detected by each method and EFF indicates the fold detection efficiency. Fold detection efficiency is calculated as the ratio of total true positive hits to the total number of structural folds in the PDB.
*Fold detection results for Cupredoxin-like proteins and 50S Ribosomal Protein L25 are obtained using the OCR-fingerprint.