Figure 2.

Computational druggability prediction of CTLRs. (A) A comprehensive account of all binding sites predicted by DoGSite is given. CTLRs were grouped according to the structure-based multiple sequence alignment. A druggability score of <0.5 is indicative of an undruggable binding site (dotted line). Binding sites are colored according to the corresponding category (red: Ca²⁺-2-binding sites (i), green: Ca²⁺-associated binding sites in long loop region (ii), blue: previously reported Ca²⁺-independent carbohydrate-binding sites (iii), gray: other binding sites). (B) A boxplot of the highest druggability scores of categories (i) to (iii) of each CTLR is shown. Tukey-style representation was chosen.