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Models for how lamin A and SUN proteins contribute to pathologies of laminopathies.
(A) A normal nucleus with lamin A (green), SUN (red), and KASH (blue) proteins at the nuclear envelope. (B) A deformed nucleus lacking lamin A with an over-accumulation of SUN proteins at the nuclear envelope. (C) The knockdown of SUN proteins rescues many of the pathologies of a lamin A mutant nucleus. See text for discussion of the four models.
