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| Phenotype | nfkb1−/− (12 weeks) | nfkb1−/− (36 weeks) | wt (12 weeks) | wt (36 weeks) | wt (104 weeks) | wt (132 weeks) |
|---|---|---|---|---|---|---|
| Enlarged spleen* | 3/5 | 6/6 | 0/5 | 0/5 | 1/7 | 4/5 |
| High systemic IL-6† | 0/5 | 5/5 | 0/4 | 2/5 | n.d. | 5/5 |
| Liver: immune cell infiltration‡ | 1/5 | 5/5 | 0/5 | 0/5 | n.d. | 2/3 |
Data are no. of animals showing the phenotype/no. of animals observed.
*Spleen mass >0.35% of body mass
†>6 pg ml−1
‡>6 CD3+ cells per field
