Table 2. Ageing-associated phenotypes in wt and nfkb1−/− mice.
| Phenotype | nfkb1−/− (36 weeks) | wt (36 weeks) | wt (104 weeks) | wt (132 weeks) |
|---|---|---|---|---|
| Low coat quality score* | 8/14 | 0/15 | 7/12 | 4/6 |
| Low body condition score† | 13/14 | 3/15 | 9/12 | 5/6 |
| Low welfare status score‡ | 7/14 | 0/15 | 9/12 | 4/6 |
| Ataxia | 1/14 | 1/15 | 3/12 | 3/6 |
| kyphosis | 0/9 | 0/15 | 0/12 | 0/6 |
| sarcopenia§ | 0/6 | 0/6 | 2/6 | 4/4 |
| Terminal weight loss|| | 3/8 | 0/24 | 6/19 | 8/9 |
| Low total body fat¶ | 6/6 | 0/5 | 0/5 | 4/5 |
| Low subcutaneous fat# | 5/6 | 0/5 | 3/7 | 5/5 |
| Cardiac hypertrophy** | 3/6 | 0/5 | 0/6 | 4/5 |
| Liver: lipofuscin | 2/3 | 1/8 | 1/4 | 6/6 |
| Liver: karyomegaly†† | 4/5 | 1/5 | 3/3 | 3/3 |
| Brain: lipofuscin | 2/5 | 0/7 | n.d. | 4/4 |
| Macroscopic tumours | 0/6 | 0/7 | 3/7 | 7/11 |
| death | 6/23 | 0/52 | 15/52 | 34/52 |
Data are no. of animals showing the phenotype/no. of animals observed.
*Alopecia, hair greying, piloerection, fur roughness scored at a scale from 1 to 10, scores below 7 are counted as low.
†Body condition67 scored at a scale from 1 to 10, scores below 7 are counted as low.
‡Physical, physiological and psychological status scored according to Hawkins et al.68 at a scale from 1 to 10, scores below 7 are counted as low.
§Mean hind leg muscle fibre diameter <36 μm
||Weight >3 g below max for >1 month
¶Total body fat=Sum (inguinal+epidymal+perirenal+mesenteric) <5% of BW
#Subcutaneous fat <0.7 g
**Heart mass >0.55% of BW
††>10% of hepatocyte nuclei