Table 2. Heat shock factor 1 (HSF1) protein expression in primary tumours related to clinicopathological variables stratified for ERα status.
|
ERα-positive patients |
ERα-negative patients |
|||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Low, n (%) | Middle, n (%) | High, n (%) | P-valuea | Low, n (%) | Middle, n (%) | High, n (%) | P-valuea |
| Age (years) |
|
|
|
0.4 |
|
|
|
0.001 |
| <66 | 55 (53) | 139 (57) | 63 (50) | 35 (58) | 34 (54) | 8 (21) | ||
| ⩾66 |
49 (47) |
103 (43) |
62 (50) |
|
25 (42) |
29 (46) |
30 (79) |
|
| FIGO-09 stage |
|
|
|
0.9 |
|
|
|
0.03 |
| l–ll | 93 (89) | 215 (89) | 113 (90) | 49 (82) | 41 (65) | 22 (58) | ||
| lll–lV |
11 (11) |
27 (11) |
12 (10) |
|
11 (18) |
22 (35) |
16 (42) |
|
| Histologic type |
|
|
|
0.001 |
|
|
|
<0.001 |
| Endometrioid | 101 (97) | 225 (93) | 105 (84) | 43 (72) | 39 (62) | 9 (24) | ||
| Nonendometrioid |
3 (3) |
17 (7) |
20 (16) |
|
17 (28) |
24 (38) |
29 (76) |
|
| Histologic grade |
|
|
|
0.004 |
|
|
|
<0.001 |
| Grade 1/2 | 86 (84) | 197 (82) | 83 (68) | 31 (53) | 19 (31) | 5 (13) | ||
| Grade 3 |
17 (16) |
44 (18) |
39 (32) |
|
28 (47) |
43 (69) |
33 (87) |
|
| Metastatic nodes |
|
|
|
0.97 |
|
|
|
0.16 |
| Negative | 83 (92) | 183 (93) | 96 (92) | 43 (86) | 36 (75) | 22 (69) | ||
| Positive |
7 (8) |
14 (7) |
8 (8) |
|
7 (14) |
12 (25) |
10 (31) |
|
| Ploidy |
|
|
|
<0.001 |
|
|
|
0.01 |
| Diploid | 57 (89) | 145 (88) | 57 (70) | 21 (72) | 31 (67) | 11 (38) | ||
| Aneuploid | 7 (11) | 20 (12) | 25 (30) | 8 (28) | 15 (33) | 18 (62) | ||
Abbreviations: ER=oestrogen receptor; FIGO=International Federation of Gynecology and Obstetrics.
Low=index 0–4, middle=index 6 and high=index 9.
a
Two-sided Pearson's χ2-test; significant P-values (<0.05) are in bold.