Table 3. Hazard ratios and 95% confidence intervals for the risk of prostate cancer per 1-unit BMI z-score in childhood according to TNM staging classification following subjects from 2004 onwards when TNM staging was introduceda.
|
|
|
|
BMI |
BMI adjusted for childhood height |
||
---|---|---|---|---|---|---|---|
Staging group | Age (years) | N | Cases | Hazard ratio | 95% Confidence interval | Hazard ratio | 95% Confidence interval |
Localised | |||||||
7 | 101 401 | 1277 | 1.07 | 1.01–1.14 | 1.06 | 0.99–1.13 | |
8 | 103 325 | 1298 | 1.07 | 1.00–1.14 | 1.05 | 0.98–1.12 | |
9 | 103 136 | 1295 | 1.05 | 0.99–1.12 | 1.03 | 0.96–1.10 | |
10 | 103 059 | 1291 | 1.06 | 0.99–1.13 | 1.04 | 0.97–1.11 | |
11 | 103 150 | 1287 | 1.05 | 0.98–1.12 | 1.02 | 0.96–1.09 | |
12 | 102 792 | 1275 | 1.05 | 0.98–1.12 | 1.02 | 0.96–1.09 | |
|
13 |
101 903 |
1256 |
1.07 |
1.00–1.14 |
1.04 |
0.97–1.11 |
Metastatic | |||||||
7 | 101 401 | 677 | 1.04 | 0.95–1.13 | 1.03 | 0.94–1.12 | |
8 | 103 325 | 687 | 1.04 | 0.95–1.13 | 1.02 | 0.93–1.12 | |
9 | 103 136 | 695 | 1.04 | 0.95–1.13 | 1.02 | 0.93–1.12 | |
10 | 103 059 | 699 | 1.02 | 0.93–1.11 | 1.00 | 0.91–1.09 | |
11 | 103 150 | 698 | 1.00 | 0.91–1.10 | 0.98 | 0.89–1.07 | |
12 | 102 792 | 694 | 0.99 | 0.91–1.08 | 0.96 | 0.88–1.06 | |
13 | 101 903 | 680 | 0.99 | 0.91–1.08 | 0.96 | 0.88–1.06 |
Abbreviations: BMI=body mass index; TNM=Tumour, Node, Metastasis.
Stratified by 5-year birth cohorts allowing the baseline hazard to differ by birth cohort.