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. 2014 May 29;111(1):68–77. doi: 10.1038/bjc.2014.282

Figure 5.

Figure 5

Fibroblast growth factor-Trap inhibits the growth of tumours in vivo. (A–D) Effects of FGF-Trap on tumour growth and body weight of mice. A total of 2 × 106 Caki-1 cells per mouse (A and C) and 5 × 106 A549 cells per mouse (B and D) were subcutaneously injected into the right flank of BALB/c nude mice. One week after implantation, mice received intraperitoneal injection of 25, 2.5 and 0.25 mg kg−1 FGF-Trap or vehicle two times weekly for 5–7 weeks, after which tumour volume (A and B) and body weight of mice (C and D) were measured (n=7–8 per group). **P<0.01, ***P<0.001, compared with vehicle group, two-way analysis of variance (ANOVA). (E and F) Photograph of the tumours. After 6–8 weeks of implantation, Caki-1 tumour-bearing mice (E) and A549 tumour-bearing mice (F) were killed and the tumours excised and photographed. The colour reproduction of this figure is available on the British Journal of Cancer journal online.