Fig. 1.
Obesity increases tumor size in KpB mice. KpB mice were fed low fat or high fat diets to induce obesity for 6 months during tumorigenesis. (A) Comparison of tumor size from non-obese and obese mice (N = 14). These mice were sacrificed 6 months after ovarian tumor induction via injection of AdCre into the ovarian bursa cavity. For the calculation of tumor size, the greatest longitudinal diameter (length) and the greatest transverse diameter (width) were determined and multiplied (m2). *p = 0.0065. (B) MRI images of tumors (arrow) from non-obese (top image) and obese (bottom image) mice demonstrate representative tumors.