Table 2.

Metabolic alterations in tumors from non-obese and obese KpB mice.

Compound name	VIPa	pb	Fold change (non-obese/obese)c	Analysis method	Identification methodd
N-glycylproline	2.27	0.0043	1.95	LC-ES+	Std
Oxidized glutathione	2.25	0.0047	3.45	LC-ES+	Std
N-acetylaspartic acid	2.22	0.0059	2.31	LC-ES−	HMDB
Vanillactic acid	2.17	0.0079	2.23	LC-ES+	HMDB
3-Amino-2-piperidone	2.14	0.0099	1.75	GCTOF	NIST
Cytidine	2.10	0.0122	4.52	LC-ES+	Std
Cytosine	2.05	0.0158	4.11	LC-ES+	Std
LysoPC(16:1(9Z))	1.99	0.0205	1.83	LC-ES+	HMDB
8-Hydroxy-deoxyguanosine	1.97	0.0230	2.45	LC-ES+	HMDB
Adenosine monophosphate	1.94	0.0257	1.61	LC-ES-	HMDB
Arginine	1.93	0.0268	1.93	LC-ES+	Std
Gluconolactone	1.89	0.0311	2.97	LC-ES+	Std
Glutathione	1.89	0.0313	3.10	LC-ES+	Std
Glutamate	1.89	0.0318	1.52	GCTOF	Std
Guanosine diphosphate	1.82	0.0404	2.39	LC-ES−	HMDB
Cytidine	1.81	0.0424	4.97	GCTOF	NIST
Inodxyl glucuronide	1.80	0.0439	3.05	LC-ES+	HMDB
Phenylethanolamine	1.80	0.0446	1.69	GCTOF	NIST
Succinic acid	1.78	0.0465	1.90	GCTOF	Std
5-Hydroxyindoleacetic acid	1.76	0.0498	1.85	LC-ES+	HMDB

^aVariable importance in the projection (VIP) was obtained from OPLS-DA with a threshold of 1.0.

^bp value was calculated from Student’s t test.

^cFold change with a value larger than 1 indicates a relatively higher concentration in tumors from non-obese (low fat diet-fed) KpB mice, while a value less than 1 means a relatively lower concentration as compared to tumors from obese (high fat diet-fed) KpB mice.

^dThe metabolites were identified by in-house library (Std), NIST library (NIST) or HMBD database (HMDB).