Table 3.
Sequence similarity (%) between the amino acid sequences of human TLR4 and those of the chimpanzee, baboon, mouse, rat, and rabbit [based on data from Ref. (44, 46, 47)].
| Animal species | Chimpanzee | Baboon | Mouse | Rat | Rabbit |
|---|---|---|---|---|---|
| Distal extracellular domain | 100 | 95 | 66 | 66 | 77 |
| Hypervariable region | 98 | 85 | 48 | 39 | 57 |
| Proximal extracellular domain | 100 | 93 | 63 | 64 | 63 |
| Transmembrane domain | 100 | 97 | 70 | 68 | 75 |
| Proximal cytoplasmic domain | 99 | 99 | 90 | 92 | |
| 85 | |||||
| Distal cytoplasmic domain | 100 | 50 | 26 | 38 |