Table 4.
Changes in blood biomarkers after vatalanib with chemoradiation
| Day-1 | 8 h | Day 1 | Day 2 | Day 9 | Day 50 | Day 70 | |
|---|---|---|---|---|---|---|---|
| P1GF | 1.42 (1.38, 1.43) | 1.61 (1.50, 1.67) | 1.60 (1.51, 1.72) | 1.61 (1.50, 1.63) | 1.54 (1.43, 1.66) | 1.57 (1.45, 1.72) | 1.57 (1.40, 1.64) |
| N =17 | N = 16 | N = 17 | N = 15 | N = 15 | N = 14 | N = 10 | |
| NA | P < 0.0001 | P < 0.0001 | P = 0.0003 | P = 0.0009 | P < 0.0001 | P = 0.027 | |
| sVEGFRl | 2.31 (2.23, 2.42) | 2.23 (2.10, 2.32) | 2.29 (2.18, 2.33) | 2.30 (2.14, 2.41) | 2.32 (2.11, 2.38) | 2.23 (2.17, 2.30) | 2.26 (2.18, 2.38) |
| N =17 | N= 16 | N= 17 | N= 15 | N= 15 | N= 14 | N= 11 | |
| NA | P = 0.0017 | P = 0.0032 | P = 0.018 | P= 0.0034 | P= 0.0004 | P = 0.46 | |
| sVEGFR2 | 3.87 (3.81, 3.92) | 3.84 (3.78, 3.90) | 3.85 (3.75, 3.90) | 3.84 (3.77, 3.89) | 3.81 (3.78, 3.89) | 3.76 (3.66, 3.87) | 3.85 (3.78, 3.89) |
| N =17 | N= 14 | N= 15 | N= 14 | N= 13 | N= 12 | N= 9 | |
| NA | P = 0.71 | P = 0.42 | P = 0.54 | P = 0.24 | P= 0.0024 | P = 0.50 | |
| sTie2 | 1.20 (0.99, 1.39) | 1.18 (0.99, 1.33) | 1.16 (0.99, 1.29) | 1.20 (0.96, 1.33) | 1.17 (1.00, 1.35) | 1.15 (0.90, 1.27) | 1.06 (0.95, 1.25) |
| N= 15 | N= 14 | N= 15 | N= 14 | N= 13 | N= 12 | N = 9 | |
| NA | P = 0.76 | P = 1.0 | P = 0.39 | P = 0.17 | P= 0.0068 | P= 0.012 | |
| MMP3 | 1.63 (1.40, 2.0) | 1.71 (1.35, 1.93) | 1.53 (1.39, 1.92) | 1.59 (1.37, 1.83) | 1.55 (1.34, 1.73) | 1.57 (1.25, 1.77) | 1.37 (1.24, 1.66) |
| N= 15 | N= 14 | N= 15 | N= 14 | N= 13 | N= 12 | N= 9 | |
| NA | P = 0.27 | P = 0.11 | P = 0.22 | P= 0.048 | P = 0.18 | P = 0.30 | |
| IL-lβ | 0.16 (0.2, 0.22) | 0.15 (0.01, 0.27) | 0.13 (0.04, 0.23) | 0.12 (0.08, 0.26) | 0.19 (0.06, 0.22) | –0.02 (0.25, 0.30) | 0.04 (0.25, 0.18) |
| N =17 | N= 16 | N =17 | N = 16 | N = 13 | N= 14 | N= 11 | |
| NA | P = 0.67 | P = 0.49 | P = 0.42 | P = 0.81 | P = 0.068 | P= 0.042 | |
| Collagen IV | 0.60 (0.65, 0.57) | 0.62 (0.65, 0.59) | 0.63 (0.66, –0.58) | 0.61 (0.74, 0.56) | 0.62 (0.67, 0.58) | 0.63 (0.69, 0.61) | 0.67 (0.7, 0.64) |
| N =17 | N= 16 | N =17 | N = 16 | N= 14 | N = 14 | N = 11 | |
| NA | P = 0.63 | P = 0.098 | P = 0.43 | P = 0.27 | P = 0.017 | P = 0.0068 | |
| CPCs | 0.92 (1.1, 0.81) | 0.86 (1.07, 0.75) | 0.87 (0.92, 0.74) | 0.9 (1.12, 0.78) | 1.1 (1.22, 0.77) | 1.1 (1.4, 1) | 1.1 (1.3,–0.98) |
| N =17 | N= 16 | N =17 | N= 15 | N= 15 | N = 13 | N= 12 | |
| NA | P = 0.28 | P = 0.19 | P = 0.95 | P = 0.24 | P = 0.0479 | P = 0.054 |
Data are shown as median fold-changes and interquartile ranges and are compared to baseline (Day-1) levels. Bold italic values represent a significant increase in the biomarker level and bold values represent a significant decrease in the biomarker level P values are from Wilcoxon test (without adjustment). A variable representing dose level was not included in the analysis