Scheme 1. Reagents and conditions: (a) For 2 (Z = N; V = Q = CH), 3 (V = N; Q = Z = CH), 4 (Q = N; V = Z = CH), and 5 (V = Z = N; Q = CH); RCO₂H (R = 3-chlorophenyl), EDC, DMAP, CH₂Cl₂, (83–94%); (b) 3-hydroxypyridine, CuI, Cs₂CO₃, Me₂NCH₂CO₂H·HCl (35–55%); (c) For 14 (W = N; Q = Z = CH; X = F; Y = Br), 15 (Q = W = N; Z = CH; X = Y = Cl), and 16 (Q = Z = N; W = CH; X = Y = Cl); 3-hydroxypyridine, K₂CO₃, DMF, microwave, 150 °C (60–93%); (d) RCONH₂ (R = 3-chlorophenyl), NaO^tBu, Pd(OAc)₂, Xantphos, PhMe, 100 °C (50-78%).