Table 3. Heteroaryl Amide SAR.

Cpd	A	R	mGlu5 pIC50a (± SEM)	mGlu5 IC50 (nM)	% Glu Maxa,b (± SEM)
51	N		<5.0c	>10,000	20d
52	N		<5.0c	>10,000	15 ± 8
53	N		<5.0c	>10,000	35 ± 6
54	CF		5.2 ± 0.11	6370	7.8 ± 2.8
55	CF		5.5 ± 0.15	3450	0.1 ± 2.4
56	CF		<4.5	>30,000	—
57	CF		<5.0c	>10,000	40 ± 9
58	CF		5.07 ± 0.05	8430	22 ± 11
59	CF		<5.0c	>10,000	40 ± 15
60	CF		<4.5	>30,000	—
61	CF		<4.5	>30,000	—
62	CF		<4.5	>30,000	—
63	CF		<4.5	>30,000	—
64	CF		<4.5	>30,000	—

^aCalcium mobilization mGlu5 assay; values are average of n ≥ 3

^bAmplitude of response in the presence of 30 μM test compound as a percentage of maximal response (100 μM glutamate); average of n ≥ 3

^cCRC does not plateau

^daverage of n = 2