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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Jun 11;24(15):3307–3314. doi: 10.1016/j.bmcl.2014.06.003

Table 6. Rat PK Results for 68 (VU0431316).

IVa,b POa,c
half-life 193 min plasma Cmax 1.12 μM
clearance 30.2 mL/min/kg plasma Tmax 240 min
VSS 2.7 L/kg AUC 8.37 μM·h
AUC 1.73 μM·h F 48%
PO tissue distribution studya,c
time plasma HPV brain B/P ratio
60 min 0.92 μM 1.31 μM 1.45 μM 1.6
a

Male Sprague-Dawley rats (n=2 per time point)

b

1 mg/kg; vehicle = 10% ethanol, 90% PEG400

c

10 mg/kg; vehicle = 10% Tween 80 in 0.5% MC