Table 5.
Average cortical and subcortical volumes of imaged participants in mm3
| PME
|
PTE
|
|||||||
|---|---|---|---|---|---|---|---|---|
| non-PME (n = 15) | PME (n = 20) | t value | p1 | non-PTE (n = 9) | PTE (n = 26) | t value | p1 | |
| Total ICV | 1,446,001.6 (195,655.4) | 1,388,466.8 (188,009.6) | –1.31 | 0.200 | 1,423,375.4 (206,228.0) | 1,409,576.2 (189,145.4) | –0.58 | 0.569 |
| Cortical gray | 325,318.5 (14,297.8) | 312,931.3 (28,508.0) | –0.57 | 0.574 | 329,127.4 (14,613.6) | 314,471.4 (25,670.3) | –1.30 | 0.205 |
| Subcortical white | 180,767.7 (31,037.5) | 170,527.2 (25,064.7) | –1.82 | 0.080 | 167,702.6 (20,155.7) | 177,412.9 (29,961.1) | 0.50 | 0.623 |
| Thalamus | 6,515.2 (668.8) | 6,360.1 (536.6) | –1.40 | 0.172 | 6,371.4 (478.6) | 6,445.7 (634.7) | –0.06 | 0.950 |
| Caudate | 4,043.4 (326.5) | 3,540.2 (272.6) | –3.67 | 0.001* | 3,961.8 (244.0) | 3,684.6 (404.3) | 0.07 | 0.942 |
| Putamen | 5,151.1 (350.9) | 4,998.4 (482.3) | –0.42 | 0.675 | 5,104.5 (367.1) | 5,049.8 (458.1) | –0.15 | 0.881 |
| Pallidum | 1,295.2 (127.2) | 1,254.8 (146.0) | –0.75 | 0.459 | 1,284.9 (131.6) | 1,267.6 (142.1) | –0.43 | 0.672 |
| Hippocampus | 3,874.6 (386.7) | 3,772.6 (329.1) | –0.89 | 0.380 | 3,908.4 (202.5) | 3,784.4 (390.4) | –0.70 | 0.491 |
Values in parentheses are SD. Volumes in each case are averaged across left and right hemispheres. No main effect of hemisphere for any structure.
1
Adjusted for prenatal MA (or TOB), marijuana, age at time of scan, gender, handedness, pulse sequence and total intracranial volume.
*
p < 0.05 after multiplicity adjustment within domain category using the step-up Hochberg Bonferroni method [60].