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. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Feb 2;32(5):1150–1157. doi: 10.1161/ATVBAHA.111.243626

Figure 3.

Figure 3

Macrophage accumulation detected by intra-aortic optical coherence tomography (OCT) and immunohistochemistry in apolipoprotein E (ApoE)−/− mice. Shown are representative intra-aortic OCT cross-sectional images and corresponding hematoxylin and eosin staining (HE), Mac-3 staining, and von Kossa staining from a 9-week ApoE−/− mouse on standard chow diet (control, top row) and a 29-week ApoE−/− mouse on high-fat diet (bottom 3 rows) are shown. Accumulation of macrophages is shown as bright back-scattered reflections on OCT images. Note the smooth, circular contour of the OCT image (top left panel), corresponding to normal wall morphology by histology.