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. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Feb 2;32(5):1150–1157. doi: 10.1161/ATVBAHA.111.243626

Figure 5.

Figure 5

Correlation between automated macrophage area quantification by optical coherence tomography and immunohistochemistry (Mac-3-positive area) in apolipoprotein E (ApoE)−/− mice for all ApoE−/− mice (A) and mice stratified by age/diet group (B). Macrophage area is represented as the mean area/cross-section. Shown are representative images of en face macrophage area (red) determined by the automatic optical coherence tomography (OCT) algorithm (C) vs Sudan IV staining for lipid accumulation (red) (D) of matched opened and pinned mouse aortas. Correlation between the automatic OCT quantified macrophage area and Sudan IV–positive lipid area in 9 ApoE−/− mice is shown in E.