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. 2014 Jul 10;5:304. doi: 10.3389/fimmu.2014.00304

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Copyright © 2014 Ohta and Sitkovsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endogenous immunoregulatory mechanisms from tiny molecule to cells. Molecular weight of CTLA-4 represents the approximate size of a homodimer. Tregs express CTLA-4 and produce IL-10 and adenosine.