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Figure 1. A mechanism for antigen transfer, cross-presentation, and priming of T-cell responses to cancer antigens. Extracellular HSP-peptide complexes engage CD91 on the surface of APCs. CD91 allows for cross-presentation of the chaperoned antigens and promotes downstream signaling cascades culminating in co-stimulation of T cells. APC, antigen-presenting cell; HSP, heat-shock protein
