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. 2014 Jan 30;10(4):662–676. doi: 10.4161/auto.27867

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Copyright © 2014 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name auto-10-662-g5.jpg — Figure 5. ERBB2-expressing Becn1^+/+ and Becn1^+/− iMMECs have similar tumor-forming capacities in nude mice. (A) Independent ERBB2-overexpressing Becn1^+/+ and Becn1^+/− iMMEC lines (e.g., A and B) were bilaterally implanted into the 3rd mammary fat pads of nude mice. Mice were monitored for tumor growth. Each data point represents the average volume of iMMEC-generated mammary tumors in 5 mice (2 tumors per mouse) per genotype ± SD (B) Representative images of ERBB2, LC3B, SQSTM1, MKI67, and cleaved CASP3 expression, as determined by IHC, in ERBB2-expressing Becn1^+/+ (Becn1^+/+;ERBB2) and ERBB2-expressing Becn1^+/− (Becn1^+/−;ERBB2) iMMEC-generated allograft mammary tumors from (A).