Table 1. T-cell responses induced by Prostvac.
Test | Result | Comment |
---|---|---|
Generation of PSA-specific T cells | 56.7% (59/104) with ≥ 2-fold increase post-vaccine | Examined 28 d after last vaccine (after expected peak response) |
Median magnitude (fold) increase in PSA-specific immune response among responders | 5-fold | Level of PSA-specific T cells in responders (30/106 PBMC) similar to level of influenza-specific T cells in same patients. |
Evidence of antigen spreading (a.k.a. antigen cascade) | 67.9% (19/28) | Immune response post-vaccine to tumor-associated antigens not in vaccine. |