Table 1.

Animal models that identify adipose tissue progenitor cells in vivo.

Study Topic	Results
Anti-adipocyte monoclonal antibody staining in fetal and postnatal pig adipose tissue 10.	Expression of adipocyte surface antigen indicates common lineage for preadipocytes, capillary endothelial cells and other stromal cells.
CD29+; CD34+ ;Sca1+; CD24+ cells isolated from the adipose stromal vascular fraction of mice followed by injection of these cells into residual fat pads of A-Zip lipodystrophic mice 28.	Reconstitution of adipose tissue in A-Zip lipodystrophic mice with CD24+ cells which are localized in perivascular location.
Adipocyte progenitors studied in SV particulates from PPARγ-GFP mouse adipose tissue and in PPARγ-GFP adipose ; Adipogenic potential of adipose tissue SV cells from PPARγ-GFP mice evaluated 29.	Adipocyte progenitors are located in the mural cell (pericytes and smooth muscle cells) compartment of the adipose tissue vasculature.
α-SMA -GFP transgenic mice: adipose tissue staining and harvest of adipose tissue stromal cells and sorted into GFP-positive (pericytes) and GFP-negative cells 61.	GFP (+) cells had multilineage differentiation ability, congregated around blood vessels and promoted vascularization in vivo and in vitro,
Living tissue imaging: confocal microscopy- based three-dimensional visualization in vivo in db/db mice 62.	Adipogenic/ angiogenic clusters contain EC's and stromal cells and are sites of active angiogenesis. Anti-VEGF inhibited angiogenesis and formation of adipogenic/ angiogenic clusters.