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A) Mesenteric fat from a B6C3F1 mouse showing a large nodule of fat necrosis in which the acellular necrotic fat cells can be seen surrounded by a thin rim of poorly cellular connective tissues (H&E). Image by courtesy of the National Toxicology Program. B) Subcutaneous tissue from a Wistar rat treated with a novel drug that produced fat necrosis. This shows acute damage.
