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Skeletal muscle from thigh of a Sprague Dawley rat treated for 3 months with a peroxisomal proliferator (WY-14643) showing a degenerative form of myopathy. In A) there focal inflammation associated with muscle fiber necrosis characterised by cytoplasmic eosinophilia and loss of cytoplasmic structure. In B) typical reparative response is seen with numerous central nuclei being visible in fibers that are variable in thickness (H&E). Images by courtesy of the National Toxicology Program.
