Table 1. Summary of properties of two NB-LRR receptors that mediate resistance to viruses. TIR-NB-LRR, toll-interleukin receptor–nucleotide-binding–leucine-rich repeat; CC-NB-LRR, coiled coil–nucleotide-binding–leucine-rich repeat; PVX, potato virus X; TMV, tobacco mosaic virus; HR, hypersensitive response.
| N | Rx | |
|---|---|---|
| Structure | TIR-NB-LRR16 | CC-NB-LRR17 |
| Chaperone complex | Interaction with SGT1-HSP90-RAR1 complex4 SGT1 affects stability8 |
NDa for interaction SGT1 affects stability2,3 |
| Localization | Predominantly nuclear5,18 | Predominantly cytoplasmic6 |
| Ligand recognition | Recognition of the helicase domain of the TMV replicase (p50) in the cytoplasm or nucleus5,18 | Recognition of PVX coat protein exclusively in cytoplasm6 |
| Signaling | Oligomerization,8 conformational change18,19 | Conformational change,20 oligomerization? |
| Interaction with transcription factors | SPL621 | NDa |
| Other interactors | 14–3-3,22 NRIP123 | RanGAP211-13 |
| Forced nuclear localization | Wild-type-like HR,5 resistance to TMV not tested | No HR established; compromised resistance to PVX6,11 |
| Forced cytoplasmic localization | No HR established; resistance to TMV not tested18 | Wild-type-like HR; slightly compromised resistance to PVX6,11 |
| Domain role in translocation | LRR possibly promotes nuclear localization,5,18 YFP-LRR co-localizes with SGT15 | LRR promotes cytoplasmic localization, CC-domain required for nuclear localization6 |
| SGT1 role in nucleocytoplasmic shuttling | Mediates nuclear import5 | Crucial for nuclear import,6 mediates nuclear import and export (Fig. 1) |
a No data available