Table 2.
Estimated Glomerular Filtration Rate (eGFR) Slopes Before Initiation of, During, and After Discontinuation of Tenofovir Disoproxil Fumarate (TDF) Exposure
| Interval, Relative to TDF Exposure | Overall (n = 834) | By Baseline eGFR |
||
|---|---|---|---|---|
| <60 mL/min/1.73 m2 (n = 24) | 60–89 mL/min/1.73 m2 (n = 322) | ≥90 mL/min/1.73 m2 (n = 477) | ||
| Before initiation | −0.9 (−1.6 to −0.2) | −5.2 (−8.4 to −2.0) | −1.4 (−2.2 to −0.5) | −0.4 (−1.5 to 0.6) |
| During | ||||
| ≤3 mo | −15.7 (−20.5 to −10.9) | −2.5 (−17.1 to 12.1) | −16.9 (−27.0 to −6.8) | −15.3 (−19.9 to −10.7) |
| >3 mo | −3.1 (−4.6 to −1.7) | −8.3 (−18.1 to 1.5) | −2.6 (−5.5 to 0.4) | −3.3 (−4.8 to −1.8) |
| After discontinuation | ||||
| ≤3 mo | 12.5 (8.9–16.1) | 23.8 (8.5–39.0) | 15.8 (10.0–21.6) | 9.5 (4.7–14.3) |
| >3 mo | 0.8 (0.1–1.5) | −0.4 (−6.4 to 5.7) | 0.3 (−0.8 to 1.4) | 1.2 (0.12–2.1) |
Data are mean values (95% confidence intervals) from a piecewise linear regression model.