Table 1. Main features of NMCP proteins and lamins. Similar characteristics are denoted in blue and different ones in red.
NMCPs | lamins | |
---|---|---|
Types |
NMCP1 (monocots 1; dicots 2‒3 genes) NMCP2 (1 gene) |
B-type (invertebrates 1; vertebrates 2‒3 genes) A-type (1 gene in vertebrates and in few invertebrates) |
Structure | Central coiled-coil rod domain, head and tail Rod domain flanked by cdk1 sites NLS in the tail domain |
Central coiled-coil rod domain, head and tail Rod domain flanked by cdk1 sites NLS in the tail domain |
Conserved regions | Extremes of the rod domain, linkers and C-terminus | Extremes of the rod domain, linkers and C-terminus |
Polimerization state | Predicted to dimerize | Dimerize and form filaments |
MW | Variable (70-200 kDa) | 65-74 kDa |
pI | Acidic | Acidic (B-type lamins); neutral (A-type) |
Solubility | NSK component | NSK component |
Subcellular localization | Lamina, nucleoplasm | Lamina, nucleoplasm |
Functions | Nuclear shape and size Chromatin organization (?) (decreased number of chromocenters but the distribution of heterochromatic regions not changed) Not involved in light induced nuclear movement |
Nuclear shape and architecture Chromatin organization and positioning Connecting NSK and CSK DNA replication, repair and transcription Cell proliferation and differentiation |
Genes | Min. 2 in most plants | Min. 3 in vertebrates, 1 in most invertebrates |
Where? | Multicellular land plants | Metazoan |