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. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: JAMA. 2009 Oct 28;302(16):1790–1795. doi: 10.1001/jama.2009.1529

Figure 1. Age-specific cumulative risk of pancreatic cancer in families with pathogenic mutations in MLH1, MSH2 or MSH6 genes.

Figure 1

MMR Carriers=families with mismatch repair gene carriers (MLH1, MSH2 or MSH6)

The penetrance curves in Figure 1 were generated by plotting the age-specific cumulative risks of pancreatic cancer (as presented in Table 3) for a set of discrete ages from 20 to 70 years at five-year intervals and then applying a smoothing spline function. The 95% Confidence Intervals corresponding to the age-specific cumulative risk of pancreatic cancer for MMR carrier families were also plotted for ages 50 to 70 years. Population estimates of age-specific cumulative risks of pancreatic cancer are given by pancreatic cancer incidence rates reported in Surveillance Epidemiology and End Results (SEER) 13, from 1992–2005 (http://seer.cancer.gov).