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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2014 May 2;22(13):3393–3404. doi: 10.1016/j.bmc.2014.04.043

Scheme 2a.

Scheme 2a

aReagents and conditions: (a) epichlorohydrin (22), K2CO3, acetone, reflux, 24 h, 67%; (b) R4H, K2CO3, EtOH, reflux, 3 h, 71–94%; (c) Ph3P, DIAD, THF, (2,2-dimethyl-1,3-dioxolan-4-yl)methanol (27), rt, 4 h; (d) 0.5 N HCl (aq.), EtOH, reflux, 2 h, 71% (two steps).