Table 3.

Circulating miRNA signatures in liver disease

Liver disease	miRNA signature	Expression	References
ALD	miR-122 (acute alcohol, microsteatosis) miR-122 and miR-155 (chronic alcohol, macrosteatosis)	Increased Increased	Zhang et al. (2010)126 Bala et al. (2012)12
NAFLD/NASH	miR-122, miRR-34a and miR-192	Increased	Cermelli et al. (2011);118 Tryndyak et al. (2012)125
HCV	miR-122, miR-34a, miR-155, miR-125b, miR-146a and miR-21	Increased	Cermelli et al. (2011);118 Bala et al. (2012);24 Zhang et al. (2012);27 Bihrer et al. (2011)32
HBV	miR-192 and miR-122	Increased	Ji, et al. (2011);119 Zhang et al. (2010)126
Liver fibrosis/ cirrhosis	miR-29 and miR-652 miR-513-3p and miR-571	Decreased Increased	Roderburg et al. (2012);52 Roderburg et al. (2011)50 Roderburg et al. (2011)50
HCC	miR-21, miR-16, miR-199a, miR-122, miR-223, and miR-885-5p	Increased	Bihrer et al. (2011);32 Tomimaru et al. (2011);123 Xu et al. (2011);121 Gui et al. (2010)122
Drug overdose	miR-122 and miR-192	Increased	Wang et al. (2009);76 Starkey Lewis et al. (2011);124 Bala et al. (2012)12

Abbreviations: ALD, alcoholic liver disease; HCC, hepatocellular carcinoma.