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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: J Immunol. 2014 Jun 16;193(2):807–816. doi: 10.4049/jimmunol.1302913

Figure 2. Tryptophan-kynurenine metabolism restricts C. difficile immunopathology.

Figure 2

A) Representative macroscopic imaging of the cecum and colon from C. difficile-infected WT versus IDO1-/- mice. The arrows indicate the areas of haemorrhage that were observed reproducibly in C. difficile-infected IDO1-/- ceca. B) Graphical representation of mouse weight fluctuations in uninfected and C. difficile-infected WT and IDO1-/- mice. Mouse weights are expressed as a percentage of original mouse weight at day 1. Uninfected controls were cefoperazone-treated similar to the infected group. Error bars represent the standard error of the mean. C) H&E staining of cecal sections from uninfected and C. difficile-infected WT versus IDO1-/- mice. D) Pathological scoring of edema, inflammation, and epithelial damage in uninfected and C. difficile-infected WT versus IDO1-/- mice. Bars represent the mean values. Uninfected controls were cefoperazone-treated similar to the infected group. Each data point represents one mouse. * P < 0.05. ** P < 0.01.