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. 2014 Jun 30;14:106. doi: 10.1186/1471-2466-14-106

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Copyright © 2014 Olfert et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Arterial serum levels of IL-1β, IL-6, TNFα and CRP obtained under resting conditions (black bar), every 10 minutes during 1-hour single-leg knee extensor exercise at 50% of maximal exercise capacity (gray bars), and every 30 minutes (up to 4 hours) during recovery post exercise (white bars), in COPD individuals with alpha-1 antitrypsin deficiency receiving augmentation therapy (AATD + AUG), AATD individuals not receiving augmentation therapy (AATD-AUG), AATD individuals with normal pulmonary function (AATD PFTnorm), non-AATD COPD patients (COPD), and age-/activity-matched controls with no lung disease (Healthy). Significant ANOVA main effect for group differences are shown above each graph. In all cases, significance is determined as p < 0.05.