Table 2.
Pooled estimates of association between genetic variant ADH1B rs1229984 (A-allele carriers v non-carriers) and cardiovascular biomarkers in all participants. (Summary effect estimates are derived from fixed effects meta-analysis and are reported as mean differences unless stated otherwise)
| Biomarker | No of studies, individuals | Effect estimate (95% CI) | P value | I2 value (%) |
|---|---|---|---|---|
| Systolic blood pressure (mm Hg) | 48, 227 559 | −0.88 (−1.19 to −0.56) | 4.1×10−8 | 26 |
| Anthropometric measures: | ||||
| Body mass index (weight (kg)/(height (m)2)) | 51, 232 570 | −0.17 (−0.24 to −0.10) | 3.4×10−6 | 52 |
| Waist circumference (cm) | 42, 140 923 | −0.34 (−0.58 to −0.10) | 6.2×10−3 | 41 |
| Inflammation: | ||||
| Log transformed interleukin 6 (% difference)* | 17, 30 950 | −5.15 (−7.82 to −2.40) | 2.90×10−4 | 33 |
| Log transformed C reactive protein (% difference)* | 42, 124 498 | −3.40 (−5.68 to −1.05) | 4.60×10−3 | 1 |
| Lipids: | ||||
| Non-HDL cholesterol (mmol/L) | 46, 202 794 | −0.03 (−0.05 to −0.01) | 5.10×10−3 | 25 |
| Log transformed triglycerides (% difference)* | 46, 205 824 | 1.61 (0.66 to 2.57) | 8.90×10−4 | 36 |
| HDL cholesterol (mmol/L) | 46, 203 440 | −0.004 (−0.012 to 0.003) | 0.259 | 54 |
*Non-normally distributed variables were natural log transformed and mean differences on the log scale were converted to percentage differences.