Table 3.

Multivariable Logistic Regressions Predicting Significantly Impaired Physical HRQOL¹ and Mental HRQOL²

	Physical HRQOL Impairment (n=211 out of 2,455)			Mental HRQOL Impairment (n=233 out of 2,455)
	OR	95% CI	p-value	OR	95% CI	p-value
(1) Model based on pre-donation characteristics
Age at donation, per 10 yearsa				0.74	(0.65, 0.86)	<0.0001
10 years after donationa,b	4.38		*	2.86		**
20 years after donationa,b	11.30			5.47
30 years after donationa,b	17.14			6.97
40 years after donationa,b	15.29			5.92
Non-white (ref: white)	2.05	(1.27, 3.30)	0.0034
1st degree relative of recipient (ref: extended relation or not related)	0.54	(0.36, 0.80)	0.0025
BMI 25–29.9 (ref: < 25)b	1.84	(1.31, 2.65)	0.0005
BMI 30–34.9 (ref: < 25)b	2.85	(1.84, 4.42)	<0.0001
BMI ≥35 (ref: < 25)b	4.32	(2.37, 7.87)	<0.0001
Education at donation (continuous, 5 levels)b	0.77	(0.64, 0.91)	0.0027	0.81	(0.70, 0.95)	0.0092
History of psychiatric difficulties prior to donation (ref: no history or unknown)a,b,c	2.46	(1.57, 3.84)	<0.0001	3.82	(2.61, 5.60)	<0.0001
Model (1) plus the following, entered one at a time:
Overall donation experience (poor – excellent)	0.79	(0.68, 0.92)	0.0024	0.67	(0.59, 0.77)	<0.0001
Recovery time compared to expected (shorter – longer)	1.26	(1.10, 1.44)	0.0008
Overall recovery time (<3 months – never)	1.63	(1.31, 2.02)	<0.0001	1.87	(1.53, 2.28)	<0.0001
Recovery time for daily activities (<3 months – never)a,b	3.05	(2.26, 4.12)	<0.0001	2.81	(2.11, 3.75)	<0.0001
I felt depressed for a while after the surgery	1.38	(1.22, 1.56)	<0.0001	1.49	(1.33, 1.67)	<0.0001
Once surgery was over, no one paid attention	1.31	(1.15, 1.49)	<0.0001	1.51	(1.34, 1.69)	<0.0001
There was support available to me from the health care providers	0.80	(0.71, 0.89)	0.0001	0.72	(0.65, 0.80)	<0.0001
My family or friends supported me throughout the donor surgery	0.78	(0.67, 0.90)	0.0007	0.69	(0.61, 0.79)	<0.0001
Comfort now with the decision to donate				0.64	(0.52, 0.78)	<0.0001
Self-reported complication (ref: no, unknown)	1.92	(1.39, 2.64)	<0.0001	2.26	(1.68, 3.03)	<0.0001
How did your donation affect your general health? (very negatively – very positively)a	0.68	(0.55, 0.84)	0.0002	0.52	(0.42, 0.64)	<0.0001
Married or partnered at questionnaire completion				0.64	(0.47, 0.86)	0.0032
Educational attainment at questionnaire completiona				0.60	(0.48, 0.76)	<0.0001

Notes: Data were missing for less than 5% of donors for all variables except educational attainment at donation (missing for 19%); missing values were multiply imputed using the sequential regression imputation method.

¹Significantly impaired physical HRQOL was defined as a PCS >−1 SD below sex-by-age norms (n=211 out of 2455) 9% of the sample.

²Significantly impaired mental HRQOL was defined as a MCS >−1 SD below sex-by-age norms (n = 233 of 2455) 9% of the sample.

^aThese variables remained significant (p < 0.01) when all variables in this table were simultaneously included in the mental HRQOL model (c-statistic = 0.760). Mental HRQOL base model c-statistic = 0.660. Additional model c-statistics for Mental HRQOL with covariates were = 0.670 to 0.705.

^bThese variables remained significant (p < 0.01) when all variables in this table were simultaneously included in the physical HRQOL model (c-statistic = 0.762). Base Model Physical HRQOL c-statistic = 0.704. Additional model c-statistics for Physical HRQOL with covariates were 0.715 to 0.741.

^cHistory of psychiatric difficulties was ascertained from medical records from the time of donation and included mentions of depression, anxiety, bi-polar disorder, post-traumatic stress disorder, and other psychiatric diagnoses.

^*Physical HRQOL: time since donation p < 0.0001, time since donation squared p = 0.0010.

^**Mental HRQOL: time since donation p = 0.0003, time since donation squared p = 0.0095.