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. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: Sci Transl Med. 2013 Aug 14;5(198):198ra107. doi: 10.1126/scitranslmed.3006637

Figure 2. HAI and IgG endpoint titers against pandemic H2N2, H3N2 and H1N1 IAV strains.

Figure 2

HAI titers were evaluated using 40 matched serum samples against A) Sing/57 H2 HA VLPs, B) HK/68 H3N2 virus or C) USSR/77 H1N1 virus. Black hatched lines indicate an HAI titer of 40, which is the conventional cutoff used to indicate seroconversion to a given HA. GMTs are depicted by red lines. IgG endpoint titers from the same sera were evaluated by ELISA against recombinant D) Jap/57 HA, E) HK/68 HA or F) USSR/77 HA, with GMTs depicted by orange lines. Data were compared using one-way repeated measures ANOVA. GMTs between exams were then compared using Tukey's multiple comparisons test. Statistically significant differences relative to exam 1 are indicated by asterisks. Ratios of IgG endpoint titers to HAI titers for G) Sing/57 IgG:Jap/57 H2 HAI, H) HK/68 H3 and I) USSR/77 H1 were then determined using the above data and plotted, with means depicted by yellow lines. Data were compared using one-way repeated measures ANOVA. Means between exams were then compared using Tukey's multiple comparisons test to determine statistically significant differences, which are denoted by asterisks.