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. 2014 Jul 10;10(7):e1003709. doi: 10.1371/journal.pcbi.1003709

Figure 4. Dynamical Network Biomarker (DNB) in cervical carcinogenesis.

Figure 4

The changes in the relevance score of the LBC1-B CpG module, termed a DNB, as a function of disease stage: the stages shown are N(HPV−), N(HPV+), preCIN2(HPV−), preCIN2(HPV+), CIN2+, CC stages 1,2 and 3. Note that the samples from stages N(HPV+), preCIN2(HPV−) and preCIN2(HPV+) were drawn from completely independent test sets and that these samples exhibit relevance scores which are intermediate between N(HPV−) and CIN2+, in line with their disease stage. Darkred dashed line indicates hypothetical switching point in the transition from cytologically normal cells at risk of CIN2+ to CIN2+. (Abbrev: N = Normal, preCIN2+: precursor CIN2+ cells, CIN2+ = cervical intraepithelial neoplasia of grade 2 or higher, CC = cervical cancer).