Figure 3. Hypogonadism and spermatogenesis defects in Fancm mutant males.

(A,B) Fancm^C4/C4 mice (12 weeks old) have smaller testes and lower epididymal sperm counts. (C–F) H&E-staining of testis sections of the indicated genotypes. Samples in panels C–D are from 16 week old males. Arrowhead points to a giant multinucleated cell. (*) indicates an example of a seminiferous tubule with abnormal spermatogenesis. Panels E and F are from 80-wk-old males. Most tubules in 80 week Fancm^C4/C4 testes have only Sertoli cells. (G) Primordial follicles quantification in mutants. * p<0.05, ** p<0.01 n>10 for each genotype.