Fig. 1.

(A) Regression plot assessing correlation between mystical experience and change in motivation to quit and (B) β values calculated from simple regressions and mediation analyses with respect to change in dependent variables (motivation to quit and cue-induced craving) for ketamine-induced dissociation (CADSS score) or mysticism (HMS score), as well as infusion type (lorazepam vs. ketamine). The correlation between mystical experience and change in motivation to quit is represented in (A), and remained significant when controlling for infusion type (lorazepam vs. ketamine 0.41 mg/kg), β = 0.678, p = 0.005. The relationship between HMS score and motivation to quit was the only association to remain significant after mediation analyses were performed (B). This suggests that mystical-type phenomena might mediate the effect of ketamine on motivation enhancement. ^* p = 0.001, ^** p = 0.012, ^*** p < 0.001, ^**** p = 0.005.