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Synthesis of Inhibitors, 3, 4, 5, 6, 7, 8, 9, 10, and 11 (Table 1). Reagents and conditions: [a] 10% NaOH (aq), MeOH, THF, 60 °C, 1 h, 94% [b]13, PyBOP, HOBt, Et3N, CH2Cl2, 23 °C, 1h, 79% [c] 4N HCl in dioxane, 23 °C, 12 h, 94% [d] appropriate sulfonyl chloride, Et3N, CH2Cl2, 0 °C to 23 °C, 1h, 23-75%.
