Table 4.

Odds ratios for developing lymphedema or arm symptoms according to presence of tumor positive lymph nodes at diagnosis by any history of radiation treatment (no/unknown vs. yes)

Variable	Lymphedemaa,c		Arm symptomsb,c
	Negative nodes	Positive nodes	Negative nodes	Positive nodes
Radiation axilla
No/unknown	1.0 (referent) n=62 Ld n=435 NLf	1.0 (referent) n=11 L n=67 NL	1.0 (referent) n=286 ASe n=435 NL	1.0 (referent) n=55 AS n=67 NL
Yes	0.55 (0.15, 1.96) n=3 L n=36 NL	7.1 (1.77, 28.58) n=9 L n=11 NL	1.53 (0.89, 2.60) n=31 AS n=36 NL	5.16 (1.85, 14.39) n=21AS n=11 NL
	Pinteraction = 0.01		Pinteraction = 0.21
Radiation breast
No/unknown	1.0 (referent) n=46 L n=320 NL	1.0 (referent) n=8 L n=59 NL	1.0 (referent) n=222 AS n=320 NL	1.0 (referent) n=45 AS n=59 NL
Yes	0.85 (0.45, 1.56) n=19 L n=151 NL	4.90 (1.43, 16.81) n=12 L n=19 NL	1.01 (0.73, 1.41) n=95 AS n=151 NL	4.29 (1.81, 10.16) n=31 AS n=19 NL
	Pinteraction = 0.04		Pinteraction = 0.02

^aComparing participants with lymphedema to participants without lymphedema or symptoms.

^bComparing participants with arm symptoms without diagnosed lymphedema to participants without lymphedema or symptoms.

^cAdjusted for baseline age, BMI (categories), history of smoking (categories and pack-years, continuous), occupational history (categories), general health at baseline (categories), tumor stage (categories), tumor size (categories), and history of chemotherapy (yes/no).

^dL = BrCa survivors with lymphedema.

^eAS = BrCa survivors with arm symptoms without a history of lymphedema.

^fNL = BrCa survivors without lymphedema or arm symptoms.