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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Trends Cell Biol. 2013 Aug 16;23(12):620–633. doi: 10.1016/j.tcb.2013.07.006

Figure 2. Oncogenic kinase signaling regulates MCL-1, BIM, and PUMA.

Figure 2

Oncogenic kinases regulate BIM, PUMA, and MCL-1 by changing gene expression, protein stability, and protein functions by activating two major pro-survival pathways: the AKT and ERK (Extracellular signal-regulated kinases) pathways. Pro-survival and pro-apoptotic pathways are denoted in blue and red, respectively.