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. Author manuscript; available in PMC: 2015 Jul 25.
Published in final edited form as: Chem Biol Interact. 2014 May 10;0:82–88. doi: 10.1016/j.cbi.2014.05.001

Figure 1. Domain structures of various basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) proteins.

Figure 1

The AhR, HIF-1α (class I), and ARNT (class II) proteins each have three distinct domains that are crucial for their function. The bHLH domain plays a role in dimerization and DNA binding. The PAS A and PAS B domains function as secondary dimerization domains. The transactivation region plays a role in interactions with other transcription coactivators. aa = amino acids.