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. Author manuscript; available in PMC: 2015 Jul 25.
Published in final edited form as: Chem Biol Interact. 2014 May 10;0:82–88. doi: 10.1016/j.cbi.2014.05.001

Figure 4. Crosstalk at the AhR-ARNT-HIF1α signaling node.

Figure 4

Top of figure: the AhR is quiescent in the cytoplasm. Ligand (L) binding activates the AhR and initiates translocation to the nucleus. In the nucleus the AhR binds to ARNT to induce transcription of XRE-containing genes. Bottom of figure: normoxic conditions lead to HIF-1α hydroxylation and degradation. In contrast, hypoxic environments cause HIF-1α stabilization and translocation to the nucleus. In the nucleus HIF-1α binds to ARNT to induce transcription of HRE-containing genes.