Table 5.

Diagnostic test characteristics of selected lactate cutpoints

Lactate cutpoint	Sensitivity % (CI)	Specificity % (CI)	NPV % (CI)	PPV % (CI)
HL*	90 (82–98)	66 (57–75)	93 (87–99)	57 (46–68)
>3.0	84 (74–94)	75 (66–84)	90 (84–97)	63 (51–75)
>4.0	72 (60–85)	88 (82–95)	86 (79–93)	75 (63–87)
>5.0	68 (55–81)	93 (88–98)	85 (78–92)	83 (71–95)

CI, confidence intervals; HL, hyperlactatemia; NPV, negative predictive value; PPV, positive predictive value.

^*Hyperlactatemia from assay defined per manufacturer as lactate concentration >2.5 mmol/L.