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. Author manuscript; available in PMC: 2015 May 28.
Published in final edited form as: Physiol Behav. 2014 Apr 13;131:7–16. doi: 10.1016/j.physbeh.2014.04.006

Fig. 6.

Fig. 6

Effect of novel wheel exposure on LH levels and Fos expression in orexin-ir and GnRH-ir neurons at ZT 8. Bars represent mean + S.E.M. (N=4/group); those with the same letter are significantly different from each other. A. Novel wheel exposure significantly reduced circulating LH levels (P<0.05). a: P<0.05. B. The percentage of GnRH-ir neurons coexpressing Fos-ir was decreased by novel wheel exposure; the locked wheel had an intermediate effect. b: P<0.01; c,d: P<0.05. C. The percentage of orexin-ir neurons co-expressing Fos-ir was increased by novel wheel presentation, with the locked wheel inducing an intermediate effect. e: P<0.001; f: P<0.01; g: P<0.05. D. The percentage of GnRH-ir neurons expressing Fos-ir was inversely correlated with the percentage of orexins-ir neurons expressing Fos-ir (P<0.001).