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Model of HBC differentiation pathways. HBCs undergo self-renewal or differentiation mainly into GBCs, which eventually produce ORNs. HBCs can also proceed toward differentiation into SUSs or BG cells, albeit at a lower frequency. Abbreviations: BG, Bowman’s gland and duct; GBC, globose basal cell; HBC, horizontal basal cell; ORN, olfactory receptor neuron; SUS, sustentacular cell.
