Figure 4.

Role of lipoxygenase (LOX) and cyclo-oxygenase (COX) pathways in AA-mediated [Ca²⁺]_i responses. AA can serve as a substrate for the LOX and COX pathways that produce metabolites (leukotrienes, prostaglandins, and prostacyclins), which can mediate inflammation and alter Ca²⁺ influx. Inhibitors of LOX (zileuton) and COX (indomethacin) did not significantly influence 10 μM AA–induced [Ca²⁺]_i oscillations, suggesting that ARC channels are specifically modulated by AA, and not by products downstream to AA. See Table 2 for summary and statistics.