Figure 6.

MIF deficiency leads to increased sensitivity to emphysematous remodeling in vivo. Lungs from Mif^+/+ and Mif^−/− animals exposed to filtered air or CS for 6 months were sectioned for morphometry. Differences in alveolar remodeling in Mif^+/+ versus Mif^−/− mice are visually apparent in CS-exposed caudal lung regions (C and D, respectively) compared with air-exposed mice (A and B, respectively). Mif^−/− mice had significantly higher mean chord length (L_m) in the caudal lung regions than Mif^+/+ when exposed to CS (E), and the change in L_m from baseline was significant in Mif^−/− mice (F). Values are expressed as means ± SEM.