Table 4. Usefulness of both IEL flow cytometric pattern and IF pattern for the diagnosis of CD in patients with lymphocytic enteritis (Marsh 1 type lesion).
Parameter | Serum anti-TG2+ | Serum anti-TG2− | Overall | ||
‘Gold standard’+n = 12 | ‘Gold standard’+n = 8 | ‘ProbableCD’ n = 7* | ‘Non-celiac’n = 43 | ‘Gold standard’+n = 20 | |
Complete FCP | 9 | 4 | 7 | 0 | 13 (65%)** |
Incomplete FCP | 3 | 3 | 0 | 2 | 6 (30%)** |
IF pattern | 8 | 4+ | 1 | 3 | 12 (60%) |
Incomplete/IF pattern | 1 | 2 | 0 | 0 | 3 (15%) |
FCP: Flow cytometric pattern.
*A GFD could not be started in 3 patients (1 not accepted, 2 non-symptomatic first degree relatives); Response to a GFD not evaluable in 4 patients (2 lost in follow-up, 2 with associated psychiatric disorders).
1 patient with an isolated CD IF pattern at inclusion developed positive EmA and the complete CD cytometric pattern in a follow-up duodenal biopsy.
**Positive FCP (65%+30% = 95%) vs positive IF pattern (60%), p = 0.039 (McNemar Test).